منابع مشابه
Focal glomerulosclerosis in the remnant kidney model--an inflammatory disease mediated by cytokines.
BACKGROUND The mechanism of progression of established renal disease remains unclear. While a low protein diet slows this progression, the role of cytokines in this process has been little investigated. METHODS We investigated cytokine expression by Northern blot and immunohistochemistry in two groups of 5/6 nephrectomized rats (5/6 Nx) fed a normal (24%) or low (6%) protein diet and compared...
متن کاملDiabetic glomerulosclerosis.
I would like to show first the glomerulus of a 92-year-old man who did not have diabetes. It is perfectly normal. I want to emphasize that in the glomerulus there is not necessarily any ageing phenomenon per se. With the electron microscope there may be a slight increase in the thickness of the basement membrane of the glomerular capillary, but it is not visible by light microscopy. In the norm...
متن کاملSecondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseas...
متن کاملUnwinding focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) represents the most common primary glomerular disease responsible for the development of end-stage renal disease (ESRD) in the United States (US). The disease progresses from podocyte injury to chronic kidney disease (CKD), ultimately leading to total nephron degeneration. Extensive basic science research has been conducted to unwind the mechanisms of F...
متن کاملKeap1 inhibition attenuates glomerulosclerosis.
BACKGROUND NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has an impact on this process. ME...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1999
ISSN: 1460-2385
DOI: 10.1093/ndt/14.suppl_1.30